Dynamic processes such as cell growth, stress responses, and differentiation are controlled by the intricate interplay of genomic and metabolic programs. To understand how cells determine their phenotypes from environmental and historical cues requires characterizing these programs in single live cells. However, almost all assays in biology are inherently destructive, severely limiting our ability to track dynamic changes over time.

My lab is interested in developing novel optical, genomic, and computational tools for non-destructive, single-cell analysis of gene regulation and metabolism. By bringing in tools from optical engineering and computational biology, we aim to tackle the toughest challenges in biology and medicine.

If you are interested, read more in Research!

We welcome trainees from a variety of backgrounds including bioengineering, biophysics, electrical engineering, computational biology, and related fields. Email Koseki (kosekik<at>uchicago.edu) if you are interested in joining us!